Tigar twas
Webb16 juli 2024 · To improve the efficiency of TWAS tools, we develop TIGAR-V2, which directly reads VCF files, enables parallel computation, and reduces up to 90% … Webb27 okt. 2024 · These findings suggest that TWAS can provide biological insight into the transcriptional regulation of complex diseases. TIGAR-V2 tool, trained Bayesian cis-eQTL …
Tigar twas
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Webbtigar Transcriptome-Integrated Genetic Association Resource (TIGAR) is developed for integrating gene-expression imputation model training, prediction, and TWAS in the same tool. Efficient handling of VCF genotype files and parallele computing have been implemented in TIGAR. Webb1 nov. 2024 · TIGAR-V2 can train gene expression imputation models using either nonparametric Bayesian Dirichlet Process Regression (DPR) or Elastic-Net (as used by PrediXcan), perform TWAS using either...
Webb16 juli 2024 · TIGAR-V2 can perform TWAS using either 60individual-level or summary-level GWAS data. Besides the burden type TWAS test [1], the 61software further implements … WebbImplement TIGAR with how-to, Q&A, fixes, code snippets. kandi ratings - Low support, No Bugs, No Vulnerabilities. No License, Build not available.
Webb1 aug. 2024 · The transcriptome-wide association studies (TWASs) that test for association between the study trait and the imputed gene expression levels from cis … WebbThe TP53-inducible glycolysis and apoptosis regulator (TIGAR) also known as fructose-2,6-bisphosphatase TIGAR is an enzyme that in humans is encoded by the C12orf5 gene. [5] [6] [7] TIGAR is a recently discovered enzyme that primarily functions as a regulator of glucose breakdown in human cells. In addition to its role in controlling glucose ...
Webb9 mars 2024 · TIGAR abrogation provides a novel adjunctive therapeutic strategy against glial tumors by increasing radiation-induced cell impairment, thus allowing the use of lower radiotherapeutic doses. These results suggest that p53 can modulate the metabolic pathways via the proteins SCO2 and TIGAR in human breast cancer.
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