Sialic acids sweeten a tumor's life

Author: grhm

August undefined, 2024

WebThe most common sialic acids are N-acetylneuraminic acid (Neu5Ac, NeuNAc or NANA), N -glycolylneuraminic acid (Neu5Glc), and N -acetyl-9- O -acetylneuraminic acid (Neu5,9Ac 2 ). 1 Substitutions may be made at carbons C4, C7, C8, and C9 and the amine located at C5, and multiple substitutions contribute to the variety of possible structures. WebFeb 24, 2024 · Sialic acid metabolism involves a series of enzymes responsible for the synthesis of CMP-sialic acid, which is the donor later used by different sialyltransferases …

Frontiers Elucidation of Functional Roles of Sialic Acids in Cancer …

WebApr 18, 2024 · Büll C Stoel MA Den Brok MH Adema GJ ‘Sialic Acids Sweeten a Tumor’s Life’ Cancer Res 74 12 2014 3,199 3,204 10.1158/0008-5472.CAN-14-0728 24830719 Search in Google Scholar [8] Teoh, ST, Ogrodzinski, MP, Ross, C, Hunter, KW, Lunt, SY. ‘Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics’, Front. WebJun 12, 2014 · Sialic Acids Sweeten a Tumor's Life Abstract. Over four decades ago, specific tumor characteristics were ascribed to the increased expression of sialic acid... son chong set

Sialic acid and biology of life: An introduction - PMC

WebSialic acid sugar-carrying glycans, sialoglycans, are aberrantly expressed on many tumor cells and have emerged as potent regulatory molecules involved in creating a tumor-supportive microenvironment. Sialoglycans can be recognized by sialic acid-binding immunoglobulin-like lectins (Siglecs), a family of immunomodulatory receptors. Most … WebSialic acids are important molecule with high structural diversity. They are known to occur in higher animals such as Echinoderms, Hemichordata, Cephalochorda, and Vertebrata and … WebMar 3, 2016 · Because the immune-inhibitory effects induced by sialylated pathogens and tumors may be attributed to different configurations of sialic acid-containing glycoproteins or glycolipids, we set out to characterize the effects of sialic acids on DCs and T-cell responses using a well-characterized neoglycoconjugate approach based on the model … son cho con trai

Don’t sugarcoat it: How glycocalyx composition influences cancer ...

Biological Functions and Analytical Strategies of Sialic …

WebSialic acids are important molecule with high structural diversity. They are known to occur in higher animals such as Echinoderms, Hemichordata, Cephalochorda, and Vertebrata and also in other animals such as Platyhelminthes, Cephalopoda, and Crustaceae. Plants are known to lack sialic acid. But they are reported to occur in viruses, bacteria ... WebJun 18, 2012 · Mechanisms and Different Pathways of Anticancer Drugs on Tumor Sialic Acids. Many research studies have shown patients with tumors that have high levels of sialyl Lewis X antigens, which appear to be linked with a poor prognosis for patients, which is one of the most conspicuous pathologic features of sias in tumors clinically [17, 18]. ... small desk trash cansWebThe total sialic acid in serum or glycolipid-bound sialic acids is significantly elevated in multiple cancers such as ovarian cancer, leukemia, colorectal cancer, and breast cancer … sonchongchay

"WebSialic acids represent a family of sugar molecules derived from neuraminic acid that frequently terminate glycan chains and contribute to many biological processes. Already … " - Sialic acids sweeten a tumor's life

Sialic acids sweeten a tumor's life

WebJun 15, 2014 · Recent findings that emphasize the detrimental effects of hypersialylation on multiple aspects of tumor growth and behavior are reviewed and novel therapeutic … WebSialic Acids Sweeten a Tumor's Life €ll, Marieke A. Stoel, Martijn H. den Brok, and Gosse J. Adema Christian Bu Abstract Over four decades ago, speciﬁc tumor characteristics were ascribed to the increased expression of sialic acid sugars on the surface of cancer cells, and this led to the deﬁnition of sialic acids as potential therapeutic ...

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WebNov 4, 2024 · The critical role of enzymes that regulate sialic acid in tumour cell growth and metastasis ... C., Stoel, M. A., den Brok, M. H. & Adema, G. J. Sialic acids sweeten a tumor’s life ... WebJan 8, 2024 · The book provides insights on the latest knowledge in the field of sialoglycobiology. Sialic acids as terminal residues of oligosaccharide chains play crucial roles in several cellular recognition events. Synthesized post translationally, they play an important role in recognition, signaling, immunological response and cell-cell interaction.

Webthe serum sialic acid levels in mice bearing tumors. Since these four antineoplastic drugs are all DNA chelating agents, it was proposed that the inhibition of tumor sialic acids by these drugs might be through DNA the template via two ways. Since we have found no effect of antineoplastic drugs on serum sialic acid levels in normal mice ... WebJun 15, 2014 · Figure 1. Aberrant sialylation favors tumor growth and progression. Several factors (e.g., oncogenes, hormones, or chemotherapy) increase the expression of …

WebHigh sialic acid content of the cancer glycocalyx has been implicated in both decreased anti-tumor activity and poorer survival outcomes (Brossart et al., 2001). Perhaps most critically, the increased sialic acid content in tumor cells increases the amount of ligands for self-inhibitory siglecs on the immune cell surface (Crocker et al., 2007). Web2. Functions of Sialic Acids in Tumor Biology Sialic acids on tumor cell surfaces are aberrantly expressed during tumor transformation and malignant progression. In general, …

WebJun 15, 2014 · Figure 1. Aberrant sialylation favors tumor growth and progression. Several factors (e.g., oncogenes, hormones, or chemotherapy) increase the expression of sialyltransferases anddownregulate the expression of sialidases (Neu) in cancer cells (red). As a result, sialoglycan synthesis in the Golgi system by sialyltransferases is enhanced …

Web2. Functions of Sialic Acids in Tumor Biology Sialic acids on tumor cell surfaces are aberrantly expressed during tumor transformation and malignant progression. In general, hypersialylation is frequently observed in tumor tissues compared to corresponding normal tissue [25]. The total sialic acid in serum or glycolipid-bound sialic acids is sonchoy portoWebMay 15, 2014 · Sialic Acids Sweeten a Tumor's Life. Updated version. 10.1158/0008-5472.CAN-14-0728 doi: Access the most recent version of this article at: Cited articles. sonchoy patroWebJan 22, 2024 · Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids … small desk whiteWebJan 22, 2024 · Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids … small desk white houseWebReview Sialic Acids Sweeten a Tumor's Life Christian B€ull, Marieke A. Stoel, Martijn H. den Brok, and Gosse J. Adema Abstract Over four decades ago, speciﬁc tumor … sonchoy patraWebNov 4, 2024 · The critical role of enzymes that regulate sialic acid in tumour cell growth and metastasis ... C., Stoel, M. A., den Brok, M. H. & Adema, G. J. Sialic acids sweeten a … son chong tham duluxWebJan 22, 2024 · Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids … sonchoy potro rate