WebDec 4, 2024 · A selective inhibitor of Cdk5, (R)-DRF053, attenuated the AGE-induced Dil-ox-LDL uptake and CD36 gene expression, whereas anti-CD36 antibody inhibited the Dil-ox-LDL uptake but not Cdk5 gene expression. The present study suggests that AGEs may stimulate ox-LDL uptake into macrophages through the Cdk5-CD36 pathway via RAGE … WebA selective inhibitor of Cdk5, (R)-DRF053, attenuated the AGE-induced Dil-ox-LDL uptake and CD36 gene expression, whereas anti-CD36 antibody inhibited the Dil-ox-LDL uptake but not Cdk5 gene expression. The present study suggests that AGEs may stimulate ox-LDL uptake into macrophages through the Cdk5–CD36 pathway via RAGE-mediated …
The structural basis for CD36 binding by the malaria …
CD36 (cluster of differentiation 36), also known as platelet glycoprotein 4, fatty acid translocase (FAT), scavenger receptor class B member 3 (SCARB3), and glycoproteins 88 (GP88), IIIb (GPIIIB), or IV (GPIV) is a protein that in humans is encoded by the CD36 gene. The CD36 antigen is an integral … See more Primary In humans, rats and mice, CD36 consists of 472 amino acids with a predicted molecular weight of approximately 53,000 Da. However, CD36 is extensively glycosylated and … See more In humans, the gene is located on the long arm of chromosome 7 at band 11.2 (7q11.2 ) and is encoded by 15 exons that extend over more than 32 kilobases. Both the 5' and the 3' untranslated regions contain introns: the 5' with two and the 3' one. Exons 1, 2 and first … See more Malaria Infections with the human malaria parasite Plasmodium falciparum are characterized by sequestration of erythrocytes infected with mature forms of the parasite and CD36 has been shown to be a major sequestration … See more CD36 has been shown to interact with FYN. See more CD36 is found on platelets, erythrocytes, monocytes, differentiated adipocytes, skeletal muscle, mammary epithelial cells, spleen cells and some skin microdermal endothelial cells See more The protein itself belongs to the class B scavenger receptor family which includes receptors for selective cholesteryl ester uptake, scavenger receptor class B type I (SR-BI) and lysosomal integral membrane protein II (LIMP-II). CD36 interacts with … See more CD36 plays a role in the regulation of angiogenesis, which may be a therapeutic strategy for controlling the spread of cancer. Some data from in vitro and animal studies … See more WebJul 31, 2024 · CD36 translocates to the plasma membrane, where an extracellular domain of the protein binds low density lipoproteins and transports them across the plasma membrane into the cytosol, thus … state theater auburn nebraska
MiR-3180 inhibits hepatocellular carcinoma growth and metastasis …
WebApr 4, 2024 · The authors further found HFD reduced the number of goblet cells, disturbed the mucin 2 secretion and thus LPS escapes the intestinal epithelial cells barrier via a transcellular pathway with the assistance of CD36. WebApr 13, 2024 · Effect of Cd36 on expression of genes involved in insulin signalling pathway and glucose metabolism. Two-way ANOVA results: P values of statistical significance for effects strain ( Cd36 genotype), type of incubation media (glucose/palmitate) and strain x substrate interaction. WebFeb 17, 2024 · Extended Data Fig. 4 CD36-deficiency results in a metabolic shift and elevated apoptosis in T reg cells. a, Indicated iT reg cells cultured in cancer cell-conditioned medium for 48 hrs (n=3 per... state theater bay city mich